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Optimized Drug Disposition

Meaning

The deliberate and strategic engineering of a therapeutic agent’s administration to ensure its entire pharmacokinetic profile—absorption, distribution, metabolism, and excretion (ADME)—results in the highest therapeutic index. In the context of hormonal health, this involves selecting the optimal delivery route and formulation to provide the target tissue with the most effective concentration of active hormone over the necessary time frame. This systematic optimization is the core principle of rational, personalized clinical pharmacology.