The desired physiological condition where intracellular and intercellular communication pathways, including those mediated by hormones, cytokines, and neurotransmitters, operate with maximal efficiency and fidelity to maintain tissue-specific function. This is the hallmark of true cellular health.
Origin
This is a modern term drawn from systems physiology, aiming to describe the ideal functional state of the cell’s communication network, which is essential for endocrine responsiveness. Optimization implies achieving peak performance across all signal transduction events.
Mechanism
Optimization involves ensuring receptor density is appropriate, ligand binding is efficient, and downstream kinase or phosphatase cascades execute their tasks without attenuation or inappropriate crosstalk. When signaling is optimized, the cell executes the correct genomic response to hormonal input.
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