Optimized Biological Aging is the clinical objective of aligning an individual’s biological age—as measured by epigenetic, cellular, and functional biomarkers—with or below their chronological age, thereby compressing the period of morbidity and extending healthspan. This state is achieved through a comprehensive, data-driven strategy that actively manages the hallmarks of aging and maintains systemic homeostasis at a youthful equilibrium. It represents a functional improvement in the rate of decline and a superior state of longevity.
Origin
This term is a cornerstone of modern preventative and longevity medicine, shifting the focus from simply treating age-related diseases to actively modifying the underlying biological aging process itself. The ‘optimized’ aspect emphasizes a personalized, high-performance approach based on objective, measurable biomarkers. It redefines the clinical goal of aging.
Mechanism
The mechanism involves maintaining telomere length, enhancing mitochondrial efficiency, reducing cellular senescence burden, and optimizing intercellular communication, all of which are modulated by the endocrine system. Strategies target the hormonal milieu to sustain youthful levels of anabolic hormones and ensure robust insulin sensitivity, thereby driving cellular repair and metabolic resilience across all tissues.
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