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Optimal T3 Delivery

Meaning

Optimal T3 Delivery is the critical therapeutic goal of ensuring that the biologically active thyroid hormone, Triiodothyronine (T3), successfully reaches its nuclear receptors in all target cells throughout the body at concentrations that are fully sufficient to maintain cellular euthyroid function. This concept requires looking beyond the mere normalization of serum T3 levels to include considerations of T3 transport proteins, the efficiency of cell membrane transporters, and the local tissue conversion efficiency. It is recognized as a non-negotiable metric for the successful and complete management of hypothyroidism.