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Optimal Mid-Normal Range

Meaning

The Optimal Mid-Normal Range is a refined clinical target for a specific biomarker, situated not just within the broad, statistically derived reference range but specifically within the central segment associated with the highest levels of health, vitality, and functional outcomes. This range represents the sweet spot where the physiological system operates with peak efficiency and resilience, often corresponding to the values observed in healthy, young adults. Clinicians focused on optimization strive to guide patient biomarkers into this more narrow, functionally superior range, recognizing that “normal” is often insufficient for “optimal.” Precision medicine requires this granular approach to biomarker interpretation.