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Optimal Free Testosterone

Meaning

Optimal Free Testosterone is the specific, clinically determined concentration of the biologically active, unbound fraction of testosterone circulating in the serum that is required to maintain peak physiological function and subjective well-being in an individual. Free testosterone, which is not bound to carrier proteins like Sex Hormone Binding Globulin (SHBG), is the only fraction readily available to diffuse into target tissues and exert its effects. Achieving this optimal level is a critical clinical objective for maximizing muscle mass, preserving bone density, supporting libido, and maintaining positive mood and cognitive function.