The beneficial impact of Omega-3 polyunsaturated fatty acids (PUFAs), specifically Eicosapentaenoic Acid (EPA) and Docosahexaenoic Acid (DHA), on the structural integrity, functional capacity, and overall well-being of the central nervous system. These essential fatty acids are vital components of neuronal cell membranes and play a direct role in cellular signaling and inflammation control within the brain. Optimizing intake supports sustained cognitive function.
Origin
This clinical concept originates from nutritional biochemistry and epidemiology, with observations linking dietary intake of fatty fish to improved cardiovascular and neurological outcomes. The term “Omega 3” refers to the chemical structure of the fatty acid, and its link to “Brain Health” is now a well-established principle in functional medicine.
Mechanism
DHA is a major structural component of neuronal and retinal cell membranes, influencing membrane fluidity and the efficiency of signal transduction. EPA and DHA are precursors to specialized pro-resolving mediators (SPMs) that actively resolve inflammation in the brain. By integrating into phospholipids, these fatty acids help regulate gene expression and mitigate chronic neuroinflammation, thereby supporting synaptic function and neuroprotection.
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