The clinical designation “Older Men” typically refers to male individuals who have progressed into the later stages of life, generally encompassing those aged 65 and above, a period characterized by predictable physiological changes and an increased prevalence of age-related conditions. In the context of hormonal health, this demographic is frequently evaluated for age-related declines in androgen levels, a condition often termed andropause or late-onset hypogonadism, which contributes to sarcopenia, decreased bone density, and metabolic shifts.
Origin
This term is a demographic classification used in public health, epidemiology, and clinical research to categorize a population subgroup for targeted study and healthcare planning. Its specific relevance in endocrinology grew as the clinical significance of age-related testosterone decline and its impact on vitality and morbidity became widely recognized.
Mechanism
The physiological mechanism associated with this demographic includes a progressive decline in the pulsatile release of GnRH from the hypothalamus, leading to decreased luteinizing hormone (LH) production by the pituitary and subsequent reduced testosterone synthesis by the testes. This hormonal shift contributes to an altered body composition, characterized by decreased lean muscle mass and increased visceral adiposity, which further exacerbates metabolic dysfunction and systemic inflammation.
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