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Obesity-Inflammation-Aromatase Axis

Meaning

The Obesity-Inflammation-Aromatase Axis describes a critical and self-perpetuating endocrine-metabolic loop that intimately links excessive visceral adipose tissue accumulation, chronic low-grade systemic inflammation, and the elevated activity of the aromatase enzyme (CYP19A1). This axis drives significant hormonal dysregulation, particularly the pathological hyperestrogenism observed in both men and women, which contributes to a higher incidence of hormone-sensitive cancers and the development of metabolic syndrome. Adipose tissue, functioning as a hyperactive endocrine organ, is central to this axis, creating a pathological environment that profoundly compromises overall physiological homeostasis. Understanding this complex interaction is vital for effective metabolic and hormonal intervention strategies.