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Obesity-Associated Hypogonadism

Meaning

Obesity-Associated Hypogonadism is a clinical syndrome characterized by diminished gonadal function, specifically reduced testosterone levels in men and often menstrual irregularities in women, directly linked to excessive adiposity. This condition is not typically due to primary gonadal failure but rather a functional suppression of the hypothalamic-pituitary-gonadal (HPG) axis. The resulting hormonal imbalance contributes to symptoms like reduced libido, fatigue, and decreased muscle mass, creating a detrimental feedback loop that exacerbates the obese state and metabolic dysfunction.