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OATP1C1 Transporter

Meaning

The OATP1C1 Transporter, or Organic Anion Transporting Polypeptide 1C1, is a specialized membrane protein critically involved in the transport of thyroid hormones across the blood-brain barrier and into specific cells within the central nervous system. This transporter exhibits a high affinity for thyroxine (T4) and reverse triiodothyronine (rT3), playing a pivotal role in delivering the precursor hormone to the brain for local conversion into the active T3. Efficient OATP1C1 function is paramount for maintaining optimal neurocognitive and metabolic health, as its impairment can lead to localized thyroid hormone deficiency in the brain.