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Nutrient Timing Signals

Meaning

Nutrient Timing Signals are the hormonal and metabolic cues generated by the ingestion of macronutrients—carbohydrates, proteins, and fats—at specific times relative to the body’s circadian rhythm and physical activity patterns. These signals, predominantly involving insulin, glucagon, and ghrelin, profoundly influence energy partitioning, muscle protein synthesis, and metabolic flexibility. Strategically managing these signals is a cornerstone of advanced clinical nutrition for optimizing body composition and managing glucose homeostasis. Mismanagement of these timing signals can lead to chronic metabolic dysregulation.