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Nrf2 Activation

Meaning

Nrf2 Activation refers to the cellular process of stimulating the Nuclear factor erythroid 2-related factor 2 (Nrf2) transcription factor, a master regulator of the body’s endogenous antioxidant and detoxification systems. Activating Nrf2 initiates the transcription of hundreds of cytoprotective genes, including those for glutathione synthesis and phase II detoxification enzymes. This mechanism is crucial for enhancing cellular resilience, combating oxidative stress, and promoting longevity by mitigating the damage caused by reactive oxygen species.