Non-Rapid Eye Movement (NREM) sleep is the collective term for the initial three stages of the sleep cycle, characterized by progressively slower brain waves and reduced physiological activity. This phase is predominantly restorative, facilitating metabolic cleanup, physical repair, and the critical release of anabolic hormones. It accounts for the majority of total sleep time in adults. This deep, quiet sleep is essential for systemic health.
Origin
The term is a fundamental classification in polysomnography, based on electroencephalogram (EEG) patterns and the absence of the rapid eye movements seen in REM sleep. The stages, N1, N2, and N3 (slow-wave sleep), represent a continuum of deepening rest. The physiological significance of NREM is deeply intertwined with endocrine rhythmicity.
Mechanism
During NREM Stage 3, or deep sleep, the brain exhibits high-amplitude, low-frequency delta waves, indicating synchronized neuronal firing. This stage is associated with the peak pulsatile secretion of growth hormone, crucial for cellular repair and energy metabolism. The homeostatic sleep drive is primarily discharged during this process, allowing for the consolidation of non-declarative memories and the reduction of synaptic overload.
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