Question 1

What is the Meaning of NR4A1?

Accepted Answer

NR4A1, or Nuclear Receptor Subfamily 4 Group A Member 1, is an orphan nuclear receptor that functions as a ligand-independent transcription factor within the cell nucleus. As an 'orphan' receptor, its endogenous activating ligand remains unknown, but its expression is rapidly induced by a variety of cellular stimuli, including stress and exercise. This protein plays a fundamental role in regulating diverse metabolic and endocrine processes.

Question 2

What is the Origin of NR4A1?

Accepted Answer

NR4A1 was originally discovered as an immediate-early response gene, meaning its expression is rapidly and transiently activated by external signals, and was first termed Nur77 or NGFI-B. It belongs to the nuclear receptor superfamily, a group of transcription factors that regulate gene expression in response to steroid and thyroid hormones. Its origin is deeply embedded in the molecular study of gene regulation and cellular signaling pathways.

Question 3

What is the Mechanism of NR4A1?

Accepted Answer

As a transcription factor, NR4A1 operates by binding to specific DNA sequences in the promoter regions of target genes, thereby modulating their expression. Its function is crucial in orchestrating metabolic programs, including the regulation of glucose homeostasis, lipid metabolism, and energy balance in key tissues like the liver, muscle, and pancreatic cells. NR4A1 also plays a role in the initial steps of steroidogenesis and is implicated in the survival and function of various endocrine cells.

NR4A1

Meaning

Origin

Mechanism

What Are the Specific Receptor Interactions of Micronized Progesterone in Vascular Cells?

Provided by the clinical team
at 4Ever Young Miami Dadeland

-15% ∞ HRTIO15

Your protocol begins with a conversation.

Visit

Schedule Appointment

About

Med & Wellness

4Ever Young Miami Dadeland

Communication

+1 786-529-6686

Email Us

Opening Hours