What is the Origin of Norepinephrine Spike?

This term is derived from neuroendocrinology and pharmacology, describing a specific, rapid kinetic event within the stress response system. Norepinephrine is synthesized in the adrenal medulla and postganglionic sympathetic neurons, and its release profile is central to autonomic function.

What is the Mechanism of Norepinephrine Spike?

The spike is triggered by an acute stressor or specific pharmacological agents, leading to the rapid exocytosis of norepinephrine-containing vesicles from nerve terminals and the adrenal medulla. Once released, norepinephrine acts on alpha and beta adrenergic receptors on target cells, rapidly initiating a cascade of effects that shunt blood flow to muscles, mobilize glucose stores, and increase overall systemic arousal, thereby preparing the organism for immediate action.

Norepinephrine Spike

Meaning

A Norepinephrine Spike is a rapid, acute surge in the concentration of the catecholamine neurotransmitter and hormone norepinephrine (also known as noradrenaline) within the synaptic clefts of the central and peripheral nervous systems, as well as in the systemic circulation. This spike is a key component of the sympathetic nervous system’s “fight-or-flight” response, resulting in immediate physiological effects such as increased heart rate, elevated blood pressure, and heightened vigilance. While useful for acute survival, frequent or excessive spikes can lead to chronic allostatic load.