A class of substances that simultaneously enhance cognitive function, such as memory, focus, and executive processing, while also reducing symptoms of anxiety and promoting a state of calm. These compounds differ from traditional anxiolytics by aiming to improve mental performance without causing sedation or cognitive impairment. In hormonal health, they are utilized to support the central nervous system’s capacity to manage stress and maintain neuroendocrine balance.
Origin
This term is a compound of nootropic (from Greek noos ‘mind’ and tropein ‘to turn/change’) and anxiolytic (anti-anxiety). The concept of enhancing cognition and reducing stress simultaneously reflects a modern, holistic approach to brain health. This therapeutic category is highly relevant in managing the psychological and cognitive symptoms associated with hormonal fluctuations.
Mechanism
Nootropic Anxiolytics typically exert their dual effects by modulating key neurotransmitter systems, such as enhancing GABAergic signaling for anxiolysis and modulating cholinergic or glutamatergic pathways for cognitive improvement. They may also interact with the HPA axis by lowering cortisol reactivity or increasing brain-derived neurotrophic factor (BDNF). This dual mechanism helps to stabilize the neuroendocrine environment, which is often destabilized by chronic stress and anxiety.
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