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Nonnative Metabolite Processing

Meaning

The biological and biochemical pathways responsible for the enzymatic transformation and subsequent elimination of substances that are foreign to the body’s normal metabolic repertoire, including pharmaceutical compounds, environmental toxins, and synthetic hormone analogs. This process, primarily carried out by the liver’s cytochrome P450 enzyme system, is essential for detoxification and maintaining internal physiological stability. In hormonal health, the processing of nonnative compounds can generate metabolites with unpredictable or adverse biological activity.