Noninvasive Neuromodulation Protocols are therapeutic techniques that alter neuronal activity in specific brain or peripheral nerve regions without requiring surgical intervention or penetration of the skin barrier. These protocols utilize external energy sources, such as electrical currents or magnetic fields, to modulate excitability and influence downstream physiological systems. In hormonal health, these techniques can target areas influencing the HPA axis or autonomic tone.
Origin
‘Noninvasive’ signifies the external application of the modality, contrasting with surgical procedures. ‘Neuromodulation’ describes the alteration of nerve activity, and ‘Protocols’ indicates the standardized, repeatable application method. This field has grown significantly with advancements in neuroimaging and electrical engineering.
Mechanism
Common mechanisms involve transcranial magnetic stimulation (TMS) inducing localized electrical fields to excite or inhibit cortical circuits, or transcutaneous vagus nerve stimulation (tVNS) which activates vagal afferents through the skin. These targeted energy deliveries modify membrane potentials of neurons, thereby altering neurotransmitter release patterns and downstream hormonal feedback signaling. The precision of the protocol dictates the functional outcome on the targeted physiological system.
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