What is the Origin of Non-Pharmacological Aging Factors?

The term explicitly excludes 'pharmacological' interventions, focusing instead on intrinsic, behavioral, and environmental drivers of senescence. 'Aging factors' points to elements recognized by gerontology as contributors to the hallmarks of aging. This categorization emphasizes self-directed health management.

What is the Mechanism of Non-Pharmacological Aging Factors?

Chronic stress elevates cortisol, which is inherently catabolic and suppresses anabolic hormone activity, accelerating tissue breakdown and impairing immune function. Inadequate sleep disrupts the pulsatile release of growth hormone and impairs glucose metabolism, further promoting an unfavorable endocrine profile. Modifying these factors restores endogenous regulatory balance, slowing the molecular progression of aging.

Non-Pharmacological Aging Factors ∞ Area

Non-Pharmacological Aging Factors

Meaning

These are modifiable lifestyle and environmental variables that significantly influence the rate and severity of biological aging independent of exogenous pharmaceutical agents or direct hormone replacement. Key factors include chronic psychological stress, persistent nutritional deficiencies, and insufficient restorative sleep patterns. Addressing these elements is foundational to healthspan extension.