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Non-Neutralizing Antibodies

Meaning

Non-Neutralizing Antibodies are a class of immune proteins that bind specifically to an antigen, such as a hormone or a peptide drug, but do not block or inactivate the biological function of that target molecule. In a clinical context, the development of these antibodies against a therapeutic peptide, like an exogenous growth factor, may complicate laboratory measurements without necessarily diminishing the drug’s intended physiological effect. They represent a distinct immunological response from the more common neutralizing antibodies.