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Non-Linear Hormone Response

Meaning

Non-Linear Hormone Response describes a physiological phenomenon where the biological effect of a hormone does not scale proportionally with its concentration, meaning small changes in hormone level can sometimes elicit a disproportionately large or even opposite effect. This response pattern is clinically crucial because it challenges the traditional dose-response model, indicating that the optimal biological concentration may be narrow and tissue-specific. Understanding this non-linearity is vital for precise hormonal therapy and accurate interpretation of endocrine testing.