What is the Origin of Non-Individualized Dosing?

This term arises from pharmacokinetics and clinical pharmacology, contrasting standardized protocols with the need for personalized adjustments. "Non-individualized" clearly denotes the absence of tailored parameters in determining the administered quantity.

What is the Mechanism of Non-Individualized Dosing?

The mechanism fails when a fixed dose bypasses the necessary individual adjustments required to achieve the desired therapeutic window at the target tissue level. A standard dose might overwhelm the metabolic capacity of one patient, leading to supra-physiological levels, while being insufficient for another whose clearance rate is accelerated. Precision in dosing requires understanding individual variance in absorption, distribution, metabolism, and excretion.

Non-Individualized Dosing ∞ Area

Non-Individualized Dosing

Meaning

Non-Individualized Dosing describes the clinical practice of applying a standardized therapeutic dose across a patient population without sufficient consideration for unique physiological variables such as receptor density, metabolic clearance rates, or body composition. This approach inherently risks therapeutic failure or adverse effects due to a lack of precision in input calibration. It contrasts sharply with precision medicine principles.