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Non-Genomic Thyroid Dysfunction

Meaning

Non-Genomic Thyroid Dysfunction refers to a disruption in the rapid, non-transcriptional actions of thyroid hormones that are mediated independently of the traditional nuclear thyroid hormone receptors. This form of dysfunction involves alterations in the immediate cellular responses, such as changes in ion channel activity, mitochondrial function, or the activation of plasma membrane-initiated signaling cascades. It is an emerging area of clinical interest, as these rapid effects significantly contribute to the overall metabolic and cardiovascular impact of thyroid hormones.