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Non-Genomic Testosterone Action

Meaning

Non-Genomic Testosterone Action refers to the rapid, extranuclear effects of testosterone that are mediated independently of the classical genomic pathway, which involves binding to the androgen receptor and altering gene transcription. These swift actions occur within seconds to minutes and involve testosterone interacting with membrane-bound receptors or signaling molecules in the cytoplasm. This pathway is a vital component of testosterone’s overall physiological impact, influencing immediate cellular functions like ion channel activity, cell signaling cascades, and cardiovascular responsiveness.