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Non-Genomic Pathway

Meaning

The Non-Genomic Pathway describes a rapid cellular signaling mechanism utilized by steroid hormones, such as estrogen and testosterone, that bypasses the traditional, slower route of direct gene transcription modulation. These effects are initiated at the cell membrane or within the cytoplasm, producing immediate physiological responses, often within seconds to minutes, unlike the hours required for genomic action. Understanding this pathway is vital for explaining the rapid effects of hormones on neuronal excitability, vascular tone, and ion transport in various endocrine target tissues.