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Non-Competitive Inhibition

Meaning

Non-Competitive Inhibition is a distinct form of enzyme regulation where an inhibitor molecule binds to an allosteric site on the enzyme, a location physically separate from the active site where the substrate binds. This binding event induces a conformational change in the enzyme’s structure that ultimately reduces its catalytic efficiency. Crucially, because the inhibitor does not compete for the active site, this form of inhibition cannot be fully overcome by simply increasing the concentration of the substrate.