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Non-Calcified Plaque

Meaning

Non-calcified plaque, often referred to as soft plaque, is an accumulation of lipid-laden macrophages, cholesterol, cellular debris, and fibrous tissue within the wall of an artery that has not yet undergone significant calcification or hardening. This type of atherosclerotic plaque is considered particularly vulnerable to rupture, which can lead to acute thrombotic events such as myocardial infarction or stroke. In the context of hormonal health, its presence is a critical marker of cardiovascular risk, often influenced by chronic metabolic and endocrine dysregulation.