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NOD2 Signaling

Meaning

NOD2 Signaling refers to the intracellular molecular pathway initiated by the Nucleotide-binding Oligomerization Domain-containing protein 2, an innate immune receptor found primarily in immune cells and Paneth cells of the intestinal lining. This signaling cascade is essential for host defense as it recognizes specific components of bacterial cell walls, such as muramyl dipeptide (MDP). The proper function of this pathway is crucial for maintaining intestinal barrier integrity and modulating the local inflammatory response.