What is the Origin of Nocturnal Growth Hormone Pulse?

The term combines "Nocturnal," referring to the night-time period, with "Growth Hormone Pulse," which describes the characteristic episodic release pattern of this peptide hormone. This phenomenon was identified through early studies on the circadian rhythm of hormone secretion.

What is the Mechanism of Nocturnal Growth Hormone Pulse?

The pulse is centrally regulated by the hypothalamus, specifically through the pulsatile release of Growth Hormone-Releasing Hormone (GHRH) and the inhibition of Somatostatin. The subsequent GH release from the pituitary gland acts on target tissues, primarily the liver, to stimulate the production of Insulin-like Growth Factor 1 (IGF-1), which mediates most of the anabolic and regenerative effects during sleep.

Nocturnal Growth Hormone Pulse

Meaning

The largest and most significant surge of Growth Hormone (GH) secretion that occurs naturally during the initial hours of deep, slow-wave sleep. This pulsatile release is a critical physiological event responsible for initiating many of the body’s repair, regeneration, and anabolic processes. The magnitude and frequency of this pulse are essential biomarkers for overall endocrine vitality and biological age.