What is the Origin of NMN Protocol?

This term is a modern construct from the field of aging research and molecular biology, following the discovery of NMN's pivotal role in NAD+ biosynthesis and its subsequent exploration as a compound with longevity-enhancing potential. The term "protocol" signifies a specific, clinically defined dosage and administration strategy for this precursor molecule.

What is the Mechanism of NMN Protocol?

Upon administration, NMN is converted to NAD+ through the action of the enzyme Nicotinamide Mononucleotide Adenylyltransferase (NMNAT) within the cell. The resulting elevated NAD+ levels then serve as a crucial co-factor for various metabolic enzymes and sirtuins, particularly SIRT1, a key regulator of cellular stress response. This enzymatic activation enhances mitochondrial function, improves insulin sensitivity, and facilitates the cellular response to metabolic stress, promoting overall cellular resilience.

NMN Protocol ∞ Area

NMN Protocol

Meaning

The NMN Protocol refers to a structured regimen involving the exogenous administration of Nicotinamide Mononucleotide (NMN), which is a direct precursor to the essential coenzyme Nicotinamide Adenine Dinucleotide (NAD+). This clinical intervention is primarily aimed at boosting systemic NAD+ levels, which are known to naturally decline significantly with advancing age. The protocol is utilized to support cellular energy metabolism, enhance DNA repair processes, and increase the activity of sirtuin longevity proteins.