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NMDA Receptor Activation

Meaning

NMDA Receptor Activation is the precise process where the N-methyl-D-aspartate (NMDA) receptor, a specific subtype of glutamate receptor, is stimulated, resulting in the opening of its integral ion channel and the subsequent influx of calcium into the postsynaptic neuron. This controlled calcium influx is a critical molecular event absolutely necessary for inducing long-term potentiation (LTP), which is the cellular mechanism widely accepted as the basis for efficient learning and memory formation. Proper, balanced activation is essential for cognitive function, but overactivation can unfortunately result in excitotoxicity and irreversible neuronal damage.