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Nighttime Metabolic Flexibility

Meaning

Nighttime Metabolic Flexibility is the physiological capacity of the body to execute an efficient and complete switch of its primary energy source from glucose utilization, which is typical during the fed state, to fatty acid oxidation during the overnight fasting period. This remarkable metabolic adaptability is a definitive hallmark of excellent metabolic health, crucial for maintaining stable blood glucose levels, optimizing nocturnal hormone production, and facilitating deep, restorative sleep architecture. Any impairment in this essential nocturnal metabolic shift can be a significant contributor to the development of insulin resistance and subsequent weight gain.