The comprehensive suite of restorative biological processes that occur predominantly during sleep, encompassing cellular repair, hormonal regulation, memory consolidation, and metabolic waste clearance. This period is physiologically crucial for resetting and optimizing systemic function for the subsequent waking cycle.
Origin
This descriptive term emphasizes the vital, regenerative nature of sleep, combining ‘nightly’ with ‘rejuvenation,’ meaning the restoration to a more youthful or vigorous state. It is a concept central to chronobiology and hormonal health.
Mechanism
Nightly rejuvenation is intricately linked to the cyclical nature of sleep stages, where deep non-REM sleep triggers the pulsatile release of Growth Hormone for tissue repair. Simultaneously, the glymphatic system actively clears neurotoxic waste from the brain, while cortisol levels reach their nadir, allowing the body to shift into a parasympathetic-dominant, anabolic state, which is essential for immune function and hormonal equilibrium.
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