What is the Origin of Nicotinamide Riboside NR?

NR was identified as a naturally occurring compound and a distinct precursor in the NAD+ salvage pathway. Its significance in human health was established through research demonstrating its unique ability to bypass a rate-limiting step in NAD+ synthesis compared to standard nicotinamide. This discovery led to its development as a leading oral intervention for boosting NAD+ levels in the context of geroscience and preventative medicine.

What is the Mechanism of Nicotinamide Riboside NR?

NR enters the cell and is phosphorylated by the enzyme Nicotinamide Riboside Kinase (NRK) to form Nicotinamide Mononucleotide (NMN), which is then rapidly converted to NAD+. By increasing the cellular pool of NAD+, NR enhances the activity of sirtuins, which are crucial regulators of metabolic health, gene silencing, and cellular stress response. This pathway supports improved mitochondrial function, which is foundational for sustained energy and tissue vitality.

Nicotinamide Riboside NR ∞ Area

Nicotinamide Riboside NR

Meaning

Nicotinamide Riboside (NR) is a form of vitamin B3 and a highly efficient precursor to the essential coenzyme Nicotinamide Adenine Dinucleotide (NAD+). It is clinically recognized as a potent compound for NAD+ restoration, targeting the age-related decline in cellular energy and metabolic function. NR is a key supplement utilized in protocols focused on metabolic optimization and healthy aging.