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NF-κB Activation

Meaning

NF-κB Activation refers to the cellular process that leads to the translocation and functional activity of the Nuclear Factor kappa-light-chain-enhancer of activated B cells (NF-κB) protein complex, a crucial transcription factor. This activation is a central event in the cellular response to stress, infection, and inflammation, controlling the expression of numerous genes involved in immune response, cell survival, and cytokine production. In the hormonal health domain, chronic NF-κB activation is often implicated in pathological states, including insulin resistance, chronic inflammatory conditions, and age-related decline, as it drives a pro-inflammatory state that can impair hormonal signaling.