What is the Origin of Next Generation Geroscience?

The term represents an evolution of the foundational Geroscience Hypothesis, which was formally established in the early 2010s by researchers at the National Institute on Aging (NIA). The "Next Generation" aspect signifies the shift from basic molecular discovery in model organisms to the design and execution of complex, proof-of-concept clinical trials in humans, utilizing advanced biomarkers of biological age.

What is the Mechanism of Next Generation Geroscience?

This discipline operates by focusing on the "Pillars of Aging," such as cellular senescence, mitochondrial dysfunction, and epigenetic alterations. Interventions target these core mechanisms to enhance cellular resilience and repair. For instance, a geroscience therapeutic might selectively clear senescent cells, thereby reducing the systemic pro-inflammatory state known as inflammaging and simultaneously improving the function of multiple organ systems.

Next Generation Geroscience ∞ Area

Next Generation Geroscience

Meaning

Next Generation Geroscience is a progressive, interdisciplinary field of study that moves beyond merely observing the effects of aging to actively targeting the fundamental biological mechanisms that drive age-related decline. This approach aims to extend the human health span by delaying, preventing, or reversing the onset of multiple chronic diseases simultaneously, rather than treating them individually after they manifest. It is the translational application of aging biology to clinical practice.