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New Dietary Ingredient (NDI)

Meaning

A New Dietary Ingredient (NDI) is defined by the United States Food and Drug Administration (FDA) as a dietary ingredient that was not marketed in the United States in a dietary supplement prior to October 15, 1994. Under the Dietary Supplement Health and Education Act (DSHEA), any supplement containing an NDI must be submitted to the FDA with a New Dietary Ingredient Notification (NDIN) at least 75 days before marketing. This is a regulatory term, not a chemical or physiological one, intended to ensure the ingredient’s safety history before public exposure. Consumers should look for supplements that have successfully navigated this process.