What is the Origin of Nevi Changes?

"Nevi" is the plural of nevus, a Latin word for a birthmark or mole. "Changes" denotes an observable shift or transformation in the characteristics of these lesions.

What is the Mechanism of Nevi Changes?

Most nevi are benign proliferations of melanocytes, the pigment-producing cells in the skin. Malignant transformation occurs when melanocytes acquire genetic mutations that lead to uncontrolled growth and invasion, often triggered by cumulative UV radiation exposure. The clinical assessment uses the ABCDE criteria—Asymmetry, Border irregularity, Color variation, Diameter greater than 6mm, and Evolving change—to identify suspicious nevi that require biopsy and histological examination.

Nevi Changes ∞ Area

Nevi Changes

Meaning

Nevi changes refer to any alteration in the appearance, size, shape, color, or texture of a nevus, commonly known as a mole, on the skin. These modifications are clinically significant because they can represent the earliest signs of malignant transformation into melanoma, a serious form of skin cancer. Diligent self-examination and professional dermatological assessment of nevi are critical components of cancer prevention and early detection, especially in patients with increased risk factors.