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Neurovascular Unit Function

Meaning

Neurovascular Unit Function describes the integrated, dynamic working relationship between neurons, glial cells (astrocytes, microglia), and the specialized cells of the cerebral vasculature (endothelial cells, pericytes) that collectively regulate cerebral blood flow and maintain the blood-brain barrier (BBB). Optimal function of this unit is essential for supplying the high metabolic demands of the brain with oxygen and glucose while simultaneously protecting it from circulating toxins and pathogens. Dysfunction in this unit is a hallmark of many neurological and neurodegenerative disorders.