What is the Origin of Neurovascular Integrity?

This term unites vascular biology with neurobiology, recognizing that neuronal health is inextricably linked to the health of its supporting vasculature. Integrity implies a state of minimal permeability and robust autoregulation within the cerebral microcirculation. Hormonal status profoundly influences the tight junctions that define this boundary.

What is the Mechanism of Neurovascular Integrity?

Integrity is maintained by endothelial cell tight junctions, pericyte function, and the coordinated signaling between neurons and local blood vessels (neurovascular coupling). Hormones influence the expression of adhesion molecules and the production of extracellular matrix components that support these structures. Deficiencies, often seen with metabolic dysregulation, can lead to BBB permeability, allowing peripheral inflammatory signals access to the brain parenchyma.

Neurovascular Integrity ∞ Area

Neurovascular Integrity

Meaning

Neurovascular Integrity describes the structural and functional coherence of the blood vessels supplying the brain and the adjacent neural tissue, encompassing the blood-brain barrier (BBB). Maintaining this integrity ensures precise regulation of nutrient delivery, waste removal, and the exclusion of circulating toxins from the central nervous system. Compromise in this area significantly impacts cognitive function and increases susceptibility to inflammation.