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Neurovascular Coupling Dynamics

Meaning

Neurovascular Coupling Dynamics refers to the rapid and localized physiological process that links neuronal activity to the subsequent changes in cerebral blood flow (CBF), ensuring that active brain regions receive a precisely matched supply of oxygen and metabolic substrates. This dynamic mechanism is essential for efficient brain function, as it dictates the delivery of glucose and the clearance of waste products. Impairment in these dynamics, often due to endothelial dysfunction or hormonal imbalance, leads to an uncoupling that contributes to cognitive impairment and is a key indicator of cerebral microvascular health.