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Neurotrophin Regulation

Meaning

Neurotrophin regulation describes the complex, homeostatic control mechanisms governing the synthesis, secretion, transport, and degradation of neurotrophic factors, which are small proteins essential for the survival, differentiation, and maintenance of neurons. This regulatory process ensures that the brain’s supply of growth factors, such as BDNF and Nerve Growth Factor (NGF), is precisely matched to local neuronal demand and systemic physiological status. Optimal neurotrophin regulation is critical for supporting neuroplasticity, cognitive health, and resilience against neurological stress. Systemic hormonal status is a major upstream regulator of this process.