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Neurotrophin Receptor Expression

Meaning

Neurotrophin receptor expression refers to the quantity and functional availability of specific transmembrane proteins, such as TrkB and p75NTR, on the surface of neurons and glial cells that bind to neurotrophic factors. The density and subtype of these receptors dictate the cell’s responsiveness to vital survival and growth signals, including Brain-Derived Neurotrophic Factor (BDNF). Clinically, the regulation of this expression is a key target for interventions aimed at promoting neuroplasticity, neuronal survival, and synaptic function. High, functional expression is an indicator of a brain environment conducive to growth and repair.