Neurotrophic Hormone Support refers to the therapeutic strategy of utilizing hormones and their modulators to promote the survival, development, and function of neurons. This support aims to enhance the synthesis and signaling of neurotrophic factors, which are essential for neuronal maintenance, synaptic integrity, and the prevention of apoptosis. Key hormones, such as Growth Hormone, IGF-1, and thyroid hormones, are integral to this process, playing a role in cognitive health and neurogenesis. Optimizing this support is a critical component of age-related cognitive decline prevention.
Origin
The term combines neurotrophic, meaning nourishing the nerves, with hormone support, highlighting the endocrine system’s role in this vital neurological process. This concept evolved from the discovery of specific neurotrophins and the subsequent realization that systemic hormones can powerfully influence their local production and activity within the central nervous system. It bridges the fields of endocrinology and neuroscience.
Mechanism
The mechanism involves the endocrine signal binding to receptors on glial cells and neurons, stimulating the expression of neurotrophic factors like Brain-Derived Neurotrophic Factor (BDNF). For example, IGF-1, whose production is stimulated by Growth Hormone, can cross the blood-brain barrier and activate pathways that suppress neuronal oxidative stress and promote mitochondrial health. This hormonal influence maintains the structural and functional plasticity of neural circuits, which is essential for learning and memory.
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