What is the Origin of Neurotrophic Factor Stimulation?

Derived from the Greek neuron (nerve) and trophe (nourishment), defining factors that nourish nerve tissue. "Stimulation" refers to the deliberate increase in their synthesis or release, often through specific physiological triggers.

What is the Mechanism of Neurotrophic Factor Stimulation?

Stimulation typically occurs downstream of positive physiological inputs like intense physical exercise or caloric restriction, activating intracellular pathways such as the CREB transcription factor. Increased BDNF then promotes synaptic strengthening by upregulating expression of synaptic proteins and receptors. This biochemical enhancement supports long-term potentiation, a cellular mechanism underlying learning and memory consolidation.

Neurotrophic Factor Stimulation

Meaning

The targeted enhancement of signaling molecules, such as Brain-Derived Neurotrophic Factor (BDNF), that support the survival, differentiation, and maintenance of neurons within the central and peripheral nervous systems. Stimulation is critical for neuroplasticity, cognitive resilience, and peripheral nerve health. We actively promote neuronal trophic support.