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Neurotrophic Factor Cascade

Meaning

The Neurotrophic Factor Cascade describes the sequential and synergistic release and activity of various neurotrophic factors, such as BDNF, Nerve Growth Factor (NGF), and Glial Cell Line-Derived Neurotrophic Factor (GDNF), that collectively regulate neuronal development, survival, and synaptic plasticity. This cascade is a fundamental biological process essential for maintaining the brain’s structural and functional health throughout the lifespan. Disruptions to this cascade are intimately linked to cognitive decline and neurodegeneration.