What is the Origin of Neurotransmitter Inhibitor?

The term originates from neurophysiology and pharmacology, a foundational concept developed with the discovery of synaptic transmission and the identification of various chemical messengers in the brain and peripheral nervous system. Classic examples include Gamma-Aminobutyric Acid (GABA) and Glycine.

What is the Mechanism of Neurotransmitter Inhibitor?

The primary mechanism of an inhibitory neurotransmitter involves binding to its specific receptor on the postsynaptic membrane, which typically causes an influx of negative ions, such as chloride, or an efflux of positive ions, such as potassium. This ion flux leads to hyperpolarization of the cell membrane, making the neuron's interior more negatively charged. This shift in membrane potential moves the cell further away from its firing threshold, effectively blocking or reducing the propagation of the nerve impulse.

Neurotransmitter Inhibitor ∞ Area

Neurotransmitter Inhibitor

Meaning

A Neurotransmitter Inhibitor is a chemical substance, either endogenous or pharmacological, that acts at the synapse to decrease the likelihood of a postsynaptic neuron generating an action potential. These compounds function to dampen or stop the transmission of an electrochemical signal, thereby regulating overall neural circuit activity. They are crucial for maintaining the delicate balance between excitation and inhibition in the central nervous system.