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Neurotransmitter Clearance

Meaning

Neurotransmitter Clearance is the essential physiological process by which chemical signaling molecules, such as serotonin, dopamine, and norepinephrine, are rapidly removed from the synaptic cleft following the transmission of a neural impulse. This precise process is executed through reuptake into the presynaptic neuron, enzymatic degradation, or diffusion away from the synapse. Efficient clearance is fundamental for maintaining the integrity of neural communication, preventing receptor overstimulation, and ensuring the brain’s rapid and adaptive response to new stimuli. Hormonal balance profoundly influences the enzymes and transporters involved in this process.