The clinical process of assessing and therapeutically adjusting the synthesis, release, receptor binding, and reuptake of key neurochemicals in the central nervous system to achieve optimal mood, cognition, and stress resilience. This optimization is crucial because neurotransmitter balance is profoundly influenced by endocrine status, and vice versa. It aims for functional equilibrium rather than pharmacological suppression.
Origin
This concept is rooted in neurochemistry and psychoneuroendocrinology, recognizing the complex interplay between the nervous system and the endocrine system. The “Optimization” goal moves beyond simply treating symptoms to achieving a state of maximal neurochemical efficiency.
Mechanism
The mechanism involves ensuring adequate precursor availability (e.g., amino acids for serotonin and dopamine synthesis), modulating the activity of key enzymes (e.g., COMT, MAO), and enhancing receptor sensitivity. Hormones like thyroid and estrogen directly influence the expression of neurotransmitter receptors and enzymes, making endocrine balance integral to this optimization.
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